Medical Care in China

Ewing sarcoma
Treatment in China

Provide a clear and complete coordinated pathway from expert assessment to treatment and rehabilitation.

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Trauma treatmentcovers complex fractures and severe limb injuries.
Precision spinal treatmentcovers cervical and lumbar spine diseases and spinal injuries.
Joint function reconstructioncovers joint replacement and complex revision.
Sports medicine techniquesprovide treatment for ligament, meniscus, and cartilage injuries.

Condition Guide

About Ewing sarcoma

Understand the condition, common triggers and treatment options that may require specialist assessment.

Disease Introduction

Ewing sarcoma is a highly malignant small round cell tumor that commonly occurs in the long bones (and also in soft tissues) of children and adolescents. It progresses rapidly and is prone to early metastasis. It is sensitive to both chemotherapy and radiotherapy, and with a combination of chemotherapy and surgery or radiotherapy, most patients in the localized stage can achieve long-term survival.


Cutting-edge high-precision diagnostic and treatment technologies

  1. Comprehensive chemotherapy regimen : The National Health Commission's "Guidelines for the Diagnosis and Treatment of Ewing Sarcoma in Children and Adolescents (2019 Edition)" recommends alternating use of VDC (vincristine + doxorubicin + cyclophosphamide) and IE (ifosfamide + etoposide), with a total treatment course of approximately 48 weeks, which is the standard systemic treatment for patients in the limited stage.
  2. Proton and heavy ion radiotherapy : Radiotherapy in children is prone to damaging growth plates and normal organs; Ruijin Hospital has been the first in Shanghai to carry out proton therapy for children and adolescents since August 2023 (23 cases have been treated, the youngest being under 4 years old), and the first domestically produced proton therapy system has treated 600 cancer patients as of April 2025; the second phase of heavy ion + proton equipment at Shanghai Proton and Heavy Ion Hospital was approved in January 2026, further expanding its service capacity.
  3. Targeted Immunotherapy Trials : The PARP inhibitor olaparib has become a research hotspot due to its interaction with the EWS-FLI1 fusion protein. However, its single-agent Phase II trial did not meet expectations, and it is currently exploring its combination with irinotecan/temozolomide. IGF-1R monoclonal antibodies and regorafenib (SARC024 Phase II) are used for relapsed and refractory patients and can be enrolled in clinical trials through sarcoma specialists.
  4. Limb-sparing local control : The 2025 GEIS guidelines and narrative review recommend that surgery should be prioritized when a negative resection margin (R0) can be achieved and function is not severely impaired; otherwise, intensity-modulated radiotherapy (IMRT) (45 Gy boosted to 64.8 Gy) should be performed. In addition, radical radiotherapy combined with chemotherapy can be used alone to avoid surgery for the spine, sacrum and other sites.

Care Overview

Ewing sarcoma Treatment in China

The medical team will develop a personalized protocol based on the pathology type, stage, genetic test, previous treatment history, and the patient's physical condition.

Leading Specialists

Trusted Expertise Across Leading Specialties

Zhou Kai

Level 4 Expert

Orthopedics

Research areas: Arthroscopic minimally invasive treatment of acute and chronic sports injuries, surgical treatment of developmental abnormalities/deformities in adolescents, and novel formulations/biological therapies for degenerative diseases. Academic Highlights: Published over 40 papers as first/corresponding author, with the highest single-paper citation count exceeding 260. Research findings were cited as annual research progress by the internationally authoritative academic organization OARSI.

West China Hospital of Sichuan University logo Affiliated Hospital West China Hospital of Sichuan University
Zhang Xianlong

Chief Physician, Level 2 Professor, Doctoral Supervisor, Head of Joint Surgery Department, Director of Robotic Clinical Application Training Center

Orthopedics

-Research areas : robotic joint replacement, complex hip and knee replacement, artificial joint revision, periprosthetic infection. - Cutting-edge technologies: China's first batch of robotic hip/knee/unicompartmental replacements; high dislocation DDH hip replacement; second-stage revision surgery for prosthesis infection. - Areas of expertise: congenital hip dysplasia, femoral head necrosis, severe osteoarthritis, rheumatoid arthritis, ankylosing spondylitis; prosthesis loosening, periprosthetic fractur

Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital logo Affiliated Hospital Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital
Yang Qingcheng

Chief Physician, Doctoral Supervisor, Director of Bone Tumor and Bone Disease Surgery

Orthopedics

Research areas : malignant tumors of bone and soft tissue, pelvic and sacral tumors, and complex bone diseases; cutting-edge technologies: 3D-printed tumor prosthesis reconstruction and pelvic and sacral tumor resection and reconstruction. Areas of expertise: osteosarcoma, chondrosarcoma, pelvic and sacral tumors, metastatic bone tumors; Academic highlights: Head of the Shanghai Bone and Soft Tissue Tumor Diagnosis and Treatment Center, Deputy Leader of the Bone Tumor Group of the Chinese Anti-Cancer Asso

Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital logo Affiliated Hospital Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital
Peng Xiaochun

Associate Chief Physician, Doctoral Supervisor, Deputy Director of the Department of Joint Surgery

Orthopedics

-Research areas : Aseptic loosening of joint prostheses, biomaterial transformation for osteoarthritis, and minimally invasive joint replacement. - Cutting-edge technologies: minimally invasive small-incision hip and knee replacement; biotherapy for osteoarthritis; research on prosthesis-osseous integration. - Areas of expertise: osteoarthritis of the hip and knee, avascular necrosis of the femoral head, developmental dysplasia of the hip; postoperative rehabilitation management after joint replacement su

Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital logo Affiliated Hospital Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital
Zhang Jianguo

Professor , specializing in early-onset scoliosis and hemivertebrae

Orthopedics

Research areas: Clinical treatment and research of early-onset severe spinal deformities, and degenerative spinal diseases. Cutting-edge technology: The clinic pioneered the "short-segment osteotomy fusion combined with dual growth rod technology" for the treatment of severe early-onset scoliosis, and has published over 40 papers. It has completed over 4,000 spinal correction surgeries, treating approximately 200 cases of spinal deformities, and has established the world's largest single-center database o

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences logo Affiliated Hospital Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Zhang Ke

Professor, Chief Physician (former head of the Joint Group)

Orthopedics

Research areas : hip joint diseases, developmental dysplasia of the hip, hip and knee replacement; cutting-edge technologies: primary replacement of complex DDH, biomechanical research of joint prostheses; Areas of expertise: Congenital hip dysplasia, avascular necrosis of the femoral head, and advanced osteoarthritis of the hip and knee; Academic highlights: A leading expert in complex hip replacement surgery in China, promoting the standardization and popularization of joint replacement in the country;

Peking University Third Hospital (PKU Third Affiliated Hospital) logo Affiliated Hospital Peking University Third Hospital (PKU Third Affiliated Hospital)

Patient Stories

See the Next Step Through Patient Journeys

Congenital Right Radial Paraaxial Hemilimb Deformity - Reshaping the Wings of a CASE 01
PATIENT JOURNEY

Congenital Right Radial Paraaxial Hemilimb Deformity - Reshaping the Wings of a "Fallen Angel" - A Dual Reconstruction of Structure and Function

OrthopedicsPediatrics

Patient records: Name: Dara Age: 5 years old Nationality: Cambodia Diagnosis: Congenital right radial paraaxial hemilimb deformity (congenital limb malformation) Treatment Hospital: Beijing Children's Hospital (Orthopedics), Capital Medical University From "no thumb" to "regaining syndesmosis," we've given wings to angels. Five-year-old Dara is from Phnom Penh, Cambodia. She's a cheerful girl, but she was born without a right thumb. Her right hand resembles a small fork, with only four fingers, making it

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Congenital Scoliosis - Unshackled by the CASE 02
PATIENT JOURNEY

Congenital Scoliosis - Unshackled by the "Butterfly Spine," Rebuilding the Pillar of Life

OrthopedicsPediatrics

Patient records: Name: Nguyen Age: 6 years old Nationality: Vietnamese Diagnosis: Congenital scoliosis (hemievertebral malformation) Treatment Hospital: Shanghai Children's Medical Center (National Children's Medical Center), affiliated with Shanghai Jiao Tong University School of Medicine Precise removal of "bad bone" straightens a curved spine. Six-year-old Nguyen Van from Hanoi, Vietnam, was shorter than other children from a young age, and a bulge on his back grew increasingly noticeable. He was afrai

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evere osteoporosis, new compression fracture of L1 vertebra - supporting the CASE 03
PATIENT JOURNEY

evere osteoporosis, new compression fracture of L1 vertebra - supporting the "flattened" spine

Orthopedics

Patient records Name: Maria Garcia Age: 75 Nationality: Philippines (Manila) Diagnosis: Severe osteoporosis, new compression fracture of L1 vertebra (Genant grade 3), accompanied by intractable pain. Treatment Hospital: Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine — Department of Orthopedics/Spinal Surgery Core technology: Percutaneous balloon dilatation kyphoplasty (PKP) In the video sent by Grandma Maria, she is wearing a brightly colored traditional F

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Complete rupture of the right anterior cruciate ligament combined with a bucket-handle tear of the medial meniscus - Repairing the CASE 04
PATIENT JOURNEY

Complete rupture of the right anterior cruciate ligament combined with a bucket-handle tear of the medial meniscus - Repairing the "ruptured" youthful dream

RehabilitationOrthopedics

Patient records Name: Lucas Martin Age: 19 Nationality: France (Lyon) Diagnosis: Complete rupture of the anterior cruciate ligament in the right knee combined with a bucket-handle tear of the medial meniscus. Treatment Hospital: Department of Sports Medicine, Huashan Hospital Affiliated to Fudan University Lucas was a rising star for Lyon's youth football team, dreaming of becoming a professional player. However, during a crucial qualifying match, a sudden stop and change of direction resulted in a loud t

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